Highly penetrant alterations of a critical region including BDNF in human psychopathology and obesity.
نویسندگان
چکیده
CONTEXT Brain-derived neurotrophic factor (BDNF) is suspected of being a causative factor in psychiatric disorders based on case reports or studies involving large structural anomalies. OBJECTIVE To determine the involvement of BDNF in human psychopathology. DESIGN Case-control study. SETTING Microarray-based comparative genomic hybridization data from 7 molecular diagnostic centers including 38 550 affected subjects and 28 705 unaffected subjects. PATIENTS Subjects referred to diagnostic screening centers for microarray-based comparative genomic hybridization for physical or cognitive impairment. MAIN OUTCOME MEASURES Genomic copy number gains and losses. RESULTS We report 5 individuals with psychopathology and genomic deletion of a critical region including BDNF. The defined critical region was never disrupted in control subjects or diagnostic cases without developmental abnormalities. CONCLUSION Hemizygosity of the BDNF region contributes to variable psychiatric phenotypes including anxiety, behavioral, and mood disorders.
منابع مشابه
Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity.
OBJECTIVE A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body ma...
متن کاملNeurotrophic Effects of Swimming and Crocin Consumption on the Rats with Obesity Induced by a High-fat Diet
Introduction: Obesity is known as a multifactorial physical disorder. On the other hand, regular sport exercises and crocin consumption have beneficial effects on obesity. In this regard, the present study aimed to investigate the effect of eight weeks of swimming training with crocin consumption on neurotrophic factors in the heart tissue of obese rats. Methods</strong...
متن کاملBDNF Contributes to the Genetic Variance of Milk Fat Yield in German Holstein Cattle
The gene encoding the brain-derived neurotrophic factor (BDNF) has been repeatedly associated with human obesity. As such, it could also contribute to the regulation of energy partitioning and the amount of secreted milk fat during lactation, which plays an important role in milk production in dairy cattle. Therefore, we performed an association study using estimated breeding values (EBVs) of b...
متن کامل11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Genomic copy number imbalances are being increasingly identified as an important cause of intellectual disability and behavioral abnormalities. The typical deletion in WAGR syndrome encompasses the PAX6 and WT1 genes, but larger deletions have been associated with neurobehavioral abnormalities and obesity. We identified four patients with overlapping interstitial deletions on 11p14.1 and extend...
متن کاملThe Effect of High Intensity Interval Training (HIIT) with Omega-3 Consumption on Plasma Level of Bdnf in Non-Athletes Male Adolescents
Introduction: The prevalence of overweight and obesity in adolescents and adults worldwide is known to be a critical health determinant that begins in childhood and continues most of the time until adulthood. Brain Drived Nurotrophic Factor Growth Factor (BDNF) stimulates and activates neuronal stem cells that proliferates and differentiates neurons, and is essential for the regulation of neuro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Archives of general psychiatry
دوره 69 12 شماره
صفحات -
تاریخ انتشار 2012